I think we'll see a lot of pounding up front as SF will run, run, run. Clark et al. will have to be strong. I think they'll run so the Smiths won't have as much of an impact, which they would if SF passes. They're going to test our front DL to the max and then try to hit Kittle on mid-length passes. Pettine has his work cut out for him this week figuring out how to get more beef in the box without letting Kittle destroy us.
On O, Rodgers is going to have to throw to that first open window and do it fast. He's not going to have time to wait for the second window as Bosa and gang will come hard. MLF and Rodgers are going to have to tire those guys out with the short, quick passing game and some plays to the sideline. I don't expect those sideline runs to work but you have to get those big guys chasing so they get a bit tired.
No prediction; just want a really good game.